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Do endogenous pollutants modify human nuclear receptors (other than the well documented oestrogen modulation)?
Posted on August 27th, 2009Categorized as Human Health Tagged as endogenous pollutants, human nuclear receptors, pollution
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As nuclear receptors make a switch (eg lipids on/off, energy conversation on/off) and the receptor ligands are small lipophilic molecules that can cause ligand-specific and tissue specific changes (a nightmare, or an opportunity, for a quantitative pharmacologist) – how can we be sure that the epidemic of obesity is not partly due to endogenous lipophilic (e.g.PPAR) common pollutant modulators that switch metabolism, rather than just eating fast food and not exercising, although this undeniably contributes. There are more than 300 compounds in our bodies now compared with prior to the industrial environment.
Pr Michael Spedding,
Chairman NC-IUPHAR,
Experimental Sciences
Institute of Research Servier
11 Rue des Moulineaux
92150 Suresnes
France
michael.spedding@fr.netgrs.com
